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[Hemorheologic parameters in coronary artery disease]
1Pécsi Orvostudományi Egyetem I. sz. Belgyógyászati Klinika, Kardiológiai Osztály.
Insights
Altered hemorheological parameters, including hematocrit and viscosity, are linked to coronary artery disease (CAD) severity. These blood flow properties may contribute to the development of ischemic heart disease (IHD).
Area of Science:
- Cardiovascular Medicine
- Hematology
- Medical Physiology
Background:
- Hemorheological parameters are recognized risk factors for ischemic heart disease (IHD).
- Understanding the relationship between hemorheology and coronary artery disease (CAD) severity is crucial for patient management.
Purpose of the Study:
- To investigate the association between hemorheological parameters and the severity of coronary artery disease (CAD).
Main Methods:
- Analysis of hemorheological parameters (hematocrit, fibrinogen, plasma viscosity, whole blood viscosity) and circulatory index (CRI) in 109 CAD patients and 59 controls.
- Patients were categorized into groups based on coronary angiogram findings: no significant CAD, single-vessel disease, and multivessel disease.
Main Results:
- IHD patients exhibited significantly higher hemorheological parameters compared to controls.
- Fibrinogen and plasma viscosity increased with CAD severity (Groups 2 & 3 vs. Group 1).
- Hematocrit and whole blood viscosity were significantly elevated in multivessel disease (Group 3) compared to other groups.
- Circulatory index (CRI) was reduced in IHD patients and further decreased in Group 3.
Conclusions:
- Hemorheological parameters are significantly altered in patients with coronary artery disease.
- These blood flow characteristics correlate with the severity of coronary artery disease.
- Hemorheological factors may play a role in the pathogenesis and progression of CAD.
Abstract:
Hemorheological parameters were proved to be primary risk factors in ischemic heart disease (IHD) by several studies. In the present study the relation of these parameters to the severity of coronary artery disease (CAD) was examined. The data of 109 patients (mean age: 55 +/- 9 yrs) undergoing coronary angiography and 59 healthy controls (mean age: 35 +/- 10 yrs) were analyzed. Hemorheological parameters [hematocrit, fibrinogen level, plasma viscosity (PV) and whole blood viscosity (WBV)] were measured and circulatory index (CRI) was calculated. Patients were classified into three groups according to their coronary vessel state based on the coronary angiogram: Group 1 (n = 19, mean age: 53 +/- 8 yrs) without significant CAD, Group 2 (n = 19, mean age: 51 +/- 11 yrs) with single vessel disease, Group 3 (n = 71, mean age: 57 +/- 8 yrs) with multivessel disease. All the measured hemorheological parameters of IHD patients were significantly higher than those of controls. Fibrinogen and PV was significantly elevated in Group 2 and 3 comparing to Group 1 (p < 0.05 and 0.01). Hematocrit and WBV was significantly increased in Group 3 comparing to Group 1 and 2 (p < 0.05). CRI was significantly decreased in IHD patients, and it was also lower in Group 3 than in Group 2 (p < 0.05). These results indicate that hemorheological parameters may play a role in the pathogenesis and development of CAD.