Related Experiment Video
Updated: Aug 9, 2026
07:46
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
[Experimental endocarditis. Pathological anatomy of human endocarditis]
L Alonso Pulpón1, C Tejero Romero, J Segovia Cubero
1Servicio de Cardiología, Clínica Puerta de Hierro, Madrid.
Revista Espanola De Cardiologia
|July 11, 1998
Summary
Researchers created animal models of infective endocarditis by inducing non-bacterial thrombotic endocarditis and then inoculating bacteria. These models aid understanding of disease mechanisms and development of treatments.
Area of Science:
- Infectious Diseases
- Cardiovascular Research
- Animal Models
Context:
- Human endocarditis research relies on animal models to mimic disease pathology.
- Non-bacterial thrombotic endocarditis (NBTE) is a key initial lesion in experimental models.
- Freedman's modified method is a widely used technique for NBTE induction.
Purpose:
- To review the methods and utility of animal models in endocarditis research.
- To highlight the role of NBTE in experimental endocarditis.
- To discuss the contribution of these models to understanding pathogenesis and treatment.
Summary:
- Experimental endocarditis models involve creating valve lesions (NBTE) and subsequent bacterial inoculation.
- Commonly, rabbits are used with Staphylococcus aureus or alpha-hemolytic Streptococcus.
- These models have been crucial for elucidating pathogenic mechanisms, identifying causative agents, and understanding predisposing factors.
Impact:
- Advanced understanding of endocarditis pathogenesis and etiology.
- Facilitated the development of diagnostic tools for endocarditis.
- Enabled the creation of effective therapeutic and prophylactic strategies for endocarditis.
More Related Videos
09:16Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
Published on: February 28, 2018
08:57En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
Published on: July 27, 2022
Related Concept Videos
01:27Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
01:15Layers of the Heart Wall
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
01:20Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
01:21Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...