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Related Experiment Videos

Ticlopidine induced colitis: a histopathological study including apoptosis

D Berrebi1, A Sautet, J F Flejou

  • 1Service d'Anatomie, Hôpital Bichat, Paris, France.

Journal of Clinical Pathology
|July 11, 1998
PubMed
Summary

Ticlopidine can cause microscopic colitis, a condition characterized by increased epithelial apoptosis in the colon. This drug-induced injury resolves upon ticlopidine withdrawal, normalizing the apoptotic index.

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Area of Science:

  • Gastroenterology
  • Pathology
  • Pharmacology

Background:

  • Microscopic colitis is an inflammatory condition of the colon.
  • Ticlopidine is an antiplatelet medication.
  • Chronic diarrhea can be a symptom of colitis.

Purpose of the Study:

  • To characterize ticlopidine-induced microscopic colitis.
  • To investigate the role of epithelial apoptosis in this condition.

Main Methods:

  • Analysis of colorectal biopsy samples from patients with ticlopidine-associated chronic diarrhea.
  • Quantification of apoptotic cells using in situ labeling (TUNEL assay).
  • Comparison with control group and samples after drug withdrawal.

Main Results:

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  • Histological examination confirmed microscopic colitis in all patients.
  • Significantly elevated apoptotic index in ticlopidine-related colitis compared to controls.
  • Apoptotic index returned to normal levels after ticlopidine withdrawal.

Conclusions:

  • Ticlopidine can induce microscopic colitis.
  • Increased epithelial apoptosis is associated with ticlopidine-induced colitis.
  • Apoptosis may play a role in drug-induced colonic injury.