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Exacerbation of atopic dermatitis after bacillus Calmette-Guérin vaccination
S J Dalton1, M R Haeney, L Patel
1Department of Child Health, University of Manchester, Booth Hall Children's Hospital, Blackley, UK.
Journal of the Royal Society of Medicine
|July 11, 1998
Abstract:
In two children with atopic dermatitis, routine vaccination with bacillus Calmette-Guérin (BCG) was followed by severe exacerbation of skin disease. If the sequence is cause and effect, a possible mechanism is stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with migration of activated lymphocytes to inflamed skin. In children with active atopic dermatitis, BCG vaccination is best deferred until remission.