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Splenectomy for hairy cell leukemia in pregnancy
G M Stiles1, L M Stanco, A Saven
1Department of Surgery, Sharp Memorial Hospital, San Diego 92123, USA.
Summary
Splenectomy safely managed hairy cell leukemia (HCL) in a pregnant patient, resolving thrombocytopenia and allowing a healthy delivery. This surgical approach is effective for antepartum HCL management.
Area of Science:
- Hematology
- Oncology
- Obstetrics
Background:
- Hairy cell leukemia (HCL) is a rare hematologic malignancy.
- Pregnancy complicates HCL treatment due to standard chemotherapy risks.
- Massive splenomegaly in pregnancy presents unique management challenges.
Observation:
- A pregnant patient presented with HCL and massive splenomegaly in the second trimester.
- Literature review revealed no established antepartum treatment plan for HCL.
- Splenectomy was considered to improve hematologic parameters and support pregnancy.
Findings:
- Splenectomy at 24 weeks gestation resolved thrombocytopenia.
- The pregnancy progressed without complications post-splenectomy.
- A healthy infant was delivered at 38 weeks gestation via cesarean section.
Implications:
- Splenectomy is a safe and effective antepartum treatment for HCL.
- This case provides a viable management strategy for pregnant HCL patients.
- Further research may explore optimal timing and outcomes of splenectomy in pregnancy.