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Interferon-containing controlled-release polymers for localized cerebral immunotherapy

M Wiranowska1, J Ransohoff, J D Weingart

  • 1Department of Anatomy, College of Medicine, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA. mwiranow@com1.med.usf.edu

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|July 11, 1998
PubMed
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Controlled-release ethylene-vinyl acetate copolymers (EVAc) successfully delivered biologically active mouse interferon-alpha/beta (Mu-IFN-alpha/beta) intracerebrally. This polymer delivery system shows feasibility for localized brain delivery of interferon.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Drug Delivery Systems

Background:

  • Ethylene-vinyl acetate copolymers (EVAc) are established for localized drug delivery.
  • Interferon (IFN) has therapeutic potential but requires effective delivery methods.

Purpose of the Study:

  • To evaluate EVAc polymers for controlled, localized intracerebral delivery of natural mouse interferon-alpha/beta (Mu-IFN-alpha/beta).

Main Methods:

  • Mu-IFN-alpha/beta was incorporated into EVAc polymers at varying concentrations.
  • In vitro and in vivo release kinetics were assessed.
  • Biological activity of released IFN was confirmed using viral cytopathic effect inhibition assays.

Main Results:

  • Released Mu-IFN-alpha/beta retained biological activity.

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  • In vitro, most IFN activity was released within 4 days.
  • In vivo, significant IFN activity was detected ipsilaterally within 24 hours, decreasing over 72 hours, with no contralateral activity.
  • Blood IFN levels increased over 4 days post-implantation.

    • Conclusions:

    • EVAc polymers enable controlled, localized intracerebral delivery of biologically active interferon.
    • This polymer-based system demonstrates feasibility for localized brain delivery of IFN.