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Brain weight does not decrease with age in adult rhesus monkeys

J G Herndon1, J Tigges, S A Klumpp

  • 1Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA. jim@rmy.emory.edu

Neurobiology of Aging
|July 14, 1998
PubMed
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Brain weight remains stable throughout adulthood in rhesus monkeys, unlike humans. This study analyzed 399 rhesus monkey necropsies, finding no age-related decline in brain mass.

Area of Science:

  • Comparative anatomy
  • Neuroscience
  • Primate research

Background:

  • Human studies indicate brain weight decreases with age.
  • Rhesus monkeys are a valuable model for human brain aging.

Purpose of the Study:

  • To investigate if rhesus monkeys exhibit age-related brain weight decline.
  • To compare brain aging patterns between humans and rhesus monkeys.

Main Methods:

  • Necropsy data from 399 adult rhesus monkeys across their lifespan.
  • Analysis included fresh brain weight, age, sex, body weight, and heart weight.
  • Multiple linear regression controlled for body weight and sex.

Main Results:

  • Significant sex differences in brain weight observed (males heavier than females).

Related Experiment Videos

  • Brain weight correlated positively with body and heart weight.
  • No significant relationship found between age and brain weight.

    • Conclusions:

    • Rhesus monkey brain weight is stable across adulthood.
    • Unlike humans, rhesus monkeys do not show age-related brain weight loss.
    • This finding is crucial for understanding primate brain aging models.