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Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a
1MRC Protein Phosphorylation Unit Department of Biochemistry University of Dundee MSI/WTB Complex Dow Street, Dundee, DD1 5EH, UK pcohen@bad.dundee.ac.uk
Chemistry & Biology
|July 15, 1998
Abstract:
A major goal of signal transduction research is to identify the substrates and roles of the many protein kinases. The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug.