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Related Experiment Videos

Effects of lower body pressure changes on pulmonary function

J R Coast1, J A O'Kroy, F M Akers

  • 1S. A. Rasmussen Exercise Physiology Laboratory, Northern Arizona University, Flagstaff, USA. Richard.Coast@nau.edu

Medicine and Science in Sports and Exercise
|July 15, 1998
PubMed
Summary

Altering thoracic blood volume impacts pulmonary function. Lower body negative pressure increased forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1.0), while positive pressure decreased them, suggesting blood volume shifts affect lung function.

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Area of Science:

  • Physiology
  • Respiratory Medicine

Background:

  • Exercise induces physiological changes, including decreased forced vital capacity (FVC).
  • Increased thoracic blood volume is a potential mechanism for exercise-induced FVC reduction.

Purpose of the Study:

  • To investigate if altered thoracic blood volume, independent of exercise, affects pulmonary function.
  • To determine the relationship between pulmonary function changes and initial lung volumes.
  • To assess if lower body pressure manipulation alters lung compliance.

Main Methods:

  • Application of 30 mm Hg lower body negative pressure (LBNP) and lower body positive pressure (LBPP) for 5 minutes.
  • Measurement of forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1.0).
  • Analysis of static pressure-volume curves to assess lung compliance.

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Main Results:

  • LBNP significantly increased FVC by ~0.15 L and FEV1.0 by ~0.18 L.
  • LBPP significantly decreased FVC by ~0.18 L and FEV1.0 by ~0.14 L.
  • Increased FVC with LBNP correlated with baseline FVC; FEV1.0 changes did not correlate significantly with baseline FEV1.0. Lung compliance remained unchanged.

Conclusions:

  • Altered thoracic blood volume contributes to pulmonary function changes observed post-exercise.
  • The primary effect of thoracic blood volume changes appears to be air displacement rather than alterations in lung mechanical properties.