Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human sex determination

A H Sinclair1

  • 1Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Victoria, Australia.

The Journal of Experimental Zoology
|July 15, 1998
PubMed
Summary
This summary is machine-generated.

Mammalian sex determination relies on the Y chromosome, which carries the testis-determining factor (TDF). This factor directs embryonic gonads to develop into testes, initiating male development. Without it, female development occurs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A duplication in a patient with 46,XX ovo-testicular disorder of sex development refines the SOX9 testis-specific regulatory region to 24 kb.

Clinical genetics·2017
Same author

DMRT1 is required for Müllerian duct formation in the chicken embryo.

Developmental biology·2015
Same author

The molecular genetics of ovarian differentiation in the avian model.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2012
Same author

Redd1 is a novel marker of testis development but is not required for normal male reproduction.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2012
Same author

Characterisation of urogenital ridge gene expression in the human embryonal carcinoma cell line NT2/D1.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2008
Same author

Avian sex determination: what, when and where?

Cytogenetic and genome research·2007
Same journal

Myosin expression in the developing ascidian embryo.

The Journal of experimental zoology·2012
Same journal

Regulation in the chick allantois.

The Journal of experimental zoology·2010
Same journal

A serologic study of conjugation in Paramecium bursaria.

The Journal of experimental zoology·2010
Same journal

Studies on flagellates from domesticated birds; the behavior of Trichomonas gallinarum in culture.

The Journal of experimental zoology·2010
Same journal

Experiments on the formed inclusions of the amphibian egg; the effect of pH and electrolytes on yolk and lipochondria.

The Journal of experimental zoology·2010
Same journal

Production of strophosomy in the chick embryo by local applications of colchicine.

The Journal of experimental zoology·2010
See all related articles

Area of Science:

  • Molecular Genetics
  • Developmental Biology
  • Human Genetics

Background:

  • Human sex determination is a complex process.
  • Mammalian sex determination is a model for organ development.
  • The Y chromosome plays a crucial role in male development.

Purpose of the Study:

  • To explain the role of the Y chromosome in mammalian sex determination.
  • To highlight the function of the testis-determining factor (TDF).
  • To describe the genetic pathway leading to male or female development.

Main Methods:

  • Review of established genetic and developmental principles.
  • Analysis of the Y chromosome's role in sex determination.
  • Examination of hormonal influences on sexual differentiation.

Related Experiment Videos

Main Results:

  • The Y chromosome contains the testis-determining factor (TDF).
  • TDF induces indifferent embryonic gonads to develop as testes.
  • Absence of TDF leads to ovarian development and female characteristics.

Conclusions:

  • The Y chromosome and TDF are essential for initiating male sex determination in mammals.
  • Subsequent male sexual differentiation is primarily hormone-driven.
  • Understanding these genetic pathways is key to comprehending mammalian development.