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[Down's syndrome and leukemia]

M Bermúdez Cortés1, A Verdeguer Miralles, C Jovaní Casano

  • 1Servicio de Oncología Pediátrica, Hospital Infantil Universitario La Fe, Valencia.

Anales Espanoles De Pediatria
|July 15, 1998
PubMed
Summary
This summary is machine-generated.

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Children with Down's syndrome (DS) have a higher risk of leukemia. Standard treatment protocols are recommended, with aggressive supportive care for toxicities, showing similar or better prognoses.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Genetics

Context:

  • Children with Down's syndrome (DS) exhibit an elevated risk for leukemia.
  • Specialized clinical management is crucial for these patients.

Purpose:

  • To review the clinical experience with acute leukemia in children with DS over a 21-year period.
  • To evaluate treatment outcomes and toxicities in this specific population.

Summary:

  • A retrospective review of 13 children with DS and acute leukemia (6 ALL, 4 AML, 3 TL) was conducted.
  • Standard treatment protocols were applied without initial modification.
  • Outcomes included complete remission in 5/6 ALL patients, limited success with AML in young children, and spontaneous remission in TL cases.
  • High rates of treatment-related toxicities were observed in nearly all patients.

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Impact:

  • Children with DS require standard leukemia protocols but benefit from aggressive supportive care due to increased toxicity incidence.
  • The prognosis for children with DS and leukemia is comparable or potentially better than for those without DS.
  • Transient leukemia (TL) in newborns is a neoplastic process that can spontaneously remit or progress to acute myeloid leukemia (AMKL).