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[A comparative study of intoxication severity in patients with acute purulent otitis media]
Abstract:
Plasma levels of medium molecular peptides (MMP) were measured and Paramecium test was made in 28 patients with acute otitis media purulenta (AOMP). Of these, 18 patients had complicating mastoiditis. The baseline results of both tests correlated with clinical symptoms of systemic endogenic intoxication. Paramecium test returned to normal after one day of treatment. Informative value of this test fell with detoxication contrary to plasma MMP value which correlated with the degree of intoxication and remained informative through detoxication being able to show even residual subclinical toxicity. The MMP test is a method of choice in assessing intoxication in patients with AOMP and its complications.
Insights
The medium molecular peptides (MMP) test effectively assesses systemic intoxication in acute otitis media purulenta (AOMP) and mastoiditis. It remains informative even with residual toxicity, unlike the Paramecium test.
Area of Science:
- Otolaryngology
- Clinical Chemistry
- Microbiology
Background:
- Acute otitis media purulenta (AOMP) can lead to systemic intoxication.
- Mastoiditis is a common complication of AOMP.
- Assessing the degree of systemic endogenic intoxication is crucial for patient management.
Purpose of the Study:
- To compare the diagnostic utility of plasma medium molecular peptides (MMP) levels and the Paramecium test in patients with AOMP and mastoiditis.
- To evaluate the effectiveness of these tests in reflecting systemic intoxication during treatment.
Main Methods:
- Plasma MMP levels and Paramecium test results were analyzed in 28 AOMP patients (18 with mastoiditis).
- Correlation between test results and clinical symptoms of systemic intoxication was assessed.
- Test informativeness was evaluated throughout the detoxification process.
Main Results:
- Both baseline MMP levels and Paramecium test results correlated with systemic intoxication symptoms.
- The Paramecium test normalized rapidly but lost informative value with treatment.
- Plasma MMP levels correlated with intoxication severity and remained informative, detecting subclinical toxicity.
Conclusions:
- The plasma MMP test is a reliable method for assessing intoxication in AOMP and mastoiditis.
- MMP testing provides a more comprehensive assessment of toxicity compared to the Paramecium test during treatment.