[Changes in systemic and local immunity in patients with acute and chronic purulent sinusitis in response to regional...

We studied the effects of regional lymphotropic immunostimulating therapy on alterations in immunoglobulins levels both in blood serum and paranasal sinuses mucosal secretion in patients with acute and chronic purulent sinusitis. Solutions of tactivin, lidase and novocain were administered into the area of the submaxillary lymph nodes. The effect was compared to that obtained after subcutaneous administration of tactivin and conventional therapy. No reliable alterations in systemic humoral immunity in response to lymphotropic immunostimulating therapy was reported in acute sinusitis, while in chronic sinusitis an increase in initially low IgA occurred. Regional lymphotropic administration of tactivin promoted a pronounced decrease in the initially elevated levels of SIgA, IgA and IgG in the secretion of paranasal mucosa in acute purulent sinusitis, and an increase of basaline lowered SIgA, a fall in the IgG concentration in chronic purulent sinusitis. This is indicative of effectiveness of this method of immunostimulator administration on local immunological reactivity of the mucous membrane.