[Colonic microenvironment in familial helicobacter infection]

Area of Science:

• Gastroenterology
• Microbiology
• Public Health

Background:

• Helicobacter pylori (H. pylori) infection is a significant cause of gastroduodenitis and duodenal ulcers.
• The role of the familial microenvironment in H. pylori transmission and associated gastritis requires further elucidation.

Purpose of the Study:

• To investigate the impact of the familial microenvironment on the development of H. pylori infection and gastritis.
• To assess changes in colonic microbiocenosis in patients with H. pylori-associated gastroenterological disorders.

Main Methods:

• Clinical and instrumental investigation of 13 families with H. pylori-related digestive diseases.
• Assessment of Helicobacter infection and gastritis prevalence within family members.
• Bacteriological studies to analyze colonic microbiocenosis composition.

Main Results:

• The familial factor significantly contributes to antral gastritis (60.0%), fundal gastritis (40.0%), and H. pylori infection (approx. 90.0%).
• Concurrent residence and shared lifestyle were key determinants of infection and gastritis within families.
• H. pylori-associated gastroenterological abnormalities correlated with symptomatic (47.5%) and severe (32.5%) changes in colonic microbiocenosis.

Conclusions:

• The family environment and shared lifestyle are critical factors in the transmission and development of H. pylori infection and gastritis.
• Comprehensive treatment of all family members, including pets, is recommended for anti-helicobacter therapy.
• Monitoring colonic microbiocenosis is essential during Helicobacter infection treatment.