Related Experiment Video
Updated: Aug 19, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Modern management of prosthetic valve anticoagulation
D J Tiede1, R A Nishimura, D A Gastineau
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic Rochester, MN 55905, USA.
Abstract:
Prosthetic heart valves have been effectively used for many years. Nonetheless, they are associated with risks of thrombosis and thromboembolic events, as well as anticoagulation-induced bleeding. Substantial changes in anticoagulation measurement and dosing have occurred during the past several years. In this review, the rationale for anticoagulation in patients with prosthetic heart valves, the changes in monitoring and dosing, and the comparison of relevant anticoagulation trials are discussed. On the basis of the existing data, new recommendations regarding lower anticoagulation levels are offered, utilizing a single value goal rather than the traditional therapeutic range. Perioperative management of anticoagulation is discussed in light of the available literature, and major drug interactions are reviewed.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Mitral Valve Prolapse II: Assessment and Management
Mitral Stenosis III: Medical Management
Endocarditis III: Medical Management
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis IV: Nursing Management

