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Related Experiment Videos

Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing

L A Johnston1, B A Edgar

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. lajohnst@fhcrc.org

Nature
|July 17, 1998
PubMed
Summary

Wingless (Wg) coordinates cell proliferation and patterning in developing Drosophila wings. It induces cell cycle arrest in G1 and G2 phases, regulating sensory bristle formation.

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Area of Science:

  • Developmental biology
  • Cell cycle regulation
  • Drosophila melanogaster research

Background:

  • Cell proliferation and fate patterning are coordinated during organ development.
  • The secreted morphogen Wingless (Wg) is crucial for cell proliferation and patterning in the Drosophila wing.
  • Wg also induces a non-proliferating cell zone for sensory bristle development.

Purpose of the Study:

  • To investigate how Wingless (Wg) coordinates cell cycle progression with cell fate patterning.
  • To elucidate the mechanisms regulating growth arrest in the developing Drosophila wing margin.

Main Methods:

  • Studying the regulation of growth arrest in the Drosophila wing.
  • Analyzing the roles of Wingless (Wg) and Notch signaling pathways.

Related Experiment Videos

  • Investigating the expression of proneural genes achaete and scute.
  • Examining the regulation of the String (Cdc25) phosphatase.

    • Main Results:

    • Wg and Notch signaling cooperate to induce cell cycle arrest in both G1 and G2 phases.
    • Wg induces G2 arrest in specific subdomains by upregulating achaete and scute, which downregulate String (Cdc25).
    • Notch signaling prevents G2 arrest in Wg-expressing cells, leading to G1 arrest.

    Conclusions:

    • Wg and Notch signaling pathways intricately regulate cell cycle arrest during Drosophila wing development.
    • Differential cell cycle arrest contributes to the precise patterning of sensory bristles at the wing margin.
    • This study reveals a novel mechanism for coordinating growth and patterning through cell cycle control.