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Non-Hodgkin's lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH
M A Dragon-Durey1, A F Goguel, C Leonard
1URA 1967 CNRS, Laboratoire de Cytogénétique et de Génétique Oncologiques, Institut Gustave Roussy, Villejuif, France.
Leukemia
|July 17, 1998
Abstract:
The nucleophosmin (NPM) gene is involved in two recurrent translocations in hematological malignancies: t(2;5) (p23;q35) in anaplastic large cell lymphoma (ALCL) and t(3;5)(q25.1;q34-35) in myelodysplasia and acute non-lymphocytic leukemia (ANLL). Using eight YACs encompassing the 5q34-q35 region, we could easily detect these two translocations. In both types of translocation, probable unexpected deletions were also discovered downstream of the breakpoint at 5q35.