Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide metabolite concentrations in maternal plasma decrease during parturition: possible transient

H Nanno1, N Sagawa, H Itoh

  • 1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Japan.

Molecular Human Reproduction
|July 17, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case of protracted suffocation death.

Nihon hoigaku zasshi = The Japanese journal of legal medicine·1992
Same author

[CT diagnosis of diffuse lung disease].

Nihon Kyobu Shikkan Gakkai zasshi·1992
Same author

Extracellular matrix formation in piecemeal necrosis: immunoelectron microscopic study.

Liver·1992
Same author

Listeric septicemia with meningitis in a neonatal calf.

The Journal of veterinary medical science·1992
Same author

[Exercise therapy on the basis of anaerobic threshold (AT)].

Kokyu to junkan. Respiration & circulation·1992
Same author

[Molecular biology of the natriuretic peptide system].

Nihon rinsho. Japanese journal of clinical medicine·1992

Maternal nitric oxide (NO) levels decrease during vaginal childbirth but not Cesarean delivery. This suggests NO synthesis is down-regulated during labor, independent of natriuretic peptides.

Area of Science:

  • Reproductive Biology
  • Biochemistry
  • Physiology

Background:

  • Nitric oxide (NO) plays a crucial role in physiological processes.
  • Understanding NO's role in parturition is essential for reproductive health.

Purpose of the Study:

  • To investigate the involvement of nitric oxide (NO) in parturition.
  • To measure maternal plasma concentrations of NO metabolites and related peptides during pregnancy and delivery.

Main Methods:

  • Maternal plasma concentrations of NO metabolites (cGMP) and natriuretic peptides (ANP, BNP) were measured.
  • Measurements were taken at various gestational ages, including vaginal and elective Cesarean deliveries.

Main Results:

  • Plasma cGMP and NO metabolite concentrations were significantly lower at vaginal delivery compared to the third trimester.

Related Experiment Videos

  • These concentrations remained low for 4 hours postpartum but returned to baseline by 24 hours.
  • No significant suppression was observed in women undergoing elective Cesarean section before labor onset.
  • Plasma ANP and BNP levels showed no significant changes, except for a slight ANP elevation post-Cesarean delivery.

    • Conclusions:

    • Maternal plasma concentrations of cGMP and NO metabolites significantly decrease during vaginal delivery.
    • This decrease is not observed in Cesarean deliveries and is independent of ANP and BNP levels.
    • Findings suggest a possible down-regulation of maternal NO synthesis during parturition.