Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Passive avoidance learning involves alpha2-noradrenergic receptors in a day old chick

A Stamatakis1, M G Stewart, C R Dermon

  • 1Department of Biology, University of Crete, Heraklion, Greece.

Neuroreport
|July 17, 1998
PubMed
Summary

Methyl-anthranilate (MeA) aversive learning in chicks was impaired by rauwolscine, an alpha2-noradrenergic antagonist. MeA training upregulated alpha2-noradrenergic receptors in the hyperstriatum ventrale, suggesting their role in aversive memory.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the benefits and usefulness of Schwartz Centre rounds in second-year medical students using clinical educator-facilitated group work session: not just "a facilitated moan"!

BMC medical education·2020
Same author

Two C++ libraries for counting trees on a phylogenetic terrace.

Bioinformatics (Oxford, England)·2018
Same author

Open access: Is there a predator at the door?

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2017
Same author

Acetabular labrum of hip joint in osteoarthritis: A qualitative original study and short review of the literature.

Journal of orthopaedic surgery (Hong Kong)·2017
Same author

Multi-rate Poisson tree processes for single-locus species delimitation under maximum likelihood and Markov chain Monte Carlo.

Bioinformatics (Oxford, England)·2017
Same author

Early life low intensity stress experience modifies acute stress effects on juvenile brain cell proliferation of European sea bass (D. Labrax).

Behavioural brain research·2016

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Pharmacology

Background:

  • Aversive learning is crucial for survival.
  • The role of noradrenergic systems in memory consolidation is complex.
  • The hyperstriatum ventrale is implicated in avian learning and memory.

Purpose of the Study:

  • To investigate the role of alpha2-noradrenergic receptors in the hyperstriatum ventrale during aversive learning in chicks.
  • To examine the effects of clonidine (agonist) and rauwolscine (antagonist) on one-trial passive avoidance memory.
  • To quantify changes in alpha2-noradrenergic receptor binding sites following aversive training.

Main Methods:

  • One-trial passive avoidance task in day-old chicks using methyl-anthranilate (MeA) as the aversive substance.

Related Experiment Videos

  • Intracerebral administration of clonidine (alpha2-noradrenergic agonist) or rauwolscine (alpha2-noradrenergic antagonist) into the intermediate hyperstriatum ventrale.
  • Quantitative receptor autoradiography with [3H]clonidine and [3H]rauwolscine to determine receptor binding properties.

    • Main Results:

    • Rauwolscine application, but not clonidine, significantly impaired memory retention when administered pre- or post-training.
    • MeA training led to a significant bilateral upregulation in the number of [3H]rauwolscine binding sites (Bmax) in the hyperstriatum ventrale.
    • No significant changes in [3H]clonidine binding sites were observed.

    Conclusions:

    • Activation of alpha2-noradrenergic receptors in the hyperstriatum ventrale is critical for aversive memory formation in chicks.
    • Aversive learning induces an increase in the density of alpha2-noradrenergic receptors, suggesting a role in memory consolidation.
    • These findings highlight the involvement of the noradrenergic system in the neurobiological mechanisms of aversive learning.