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The effect of environment on the changes in calmodulin in rat brain produced by repeated amphetamine treatment
M M Ostrander1, J Hartman, A Badiani
1Neuroscience and Biopsychology Programs, Departments of Psychology and Pharmacology, The University of Michigan, 525 East University St. , Ann Arbor, MI 48109-1109, USA.
Brain Research
|July 17, 1998
Abstract:
Rats were given repeated infusions of i.v. amphetamine in association with placement in a novel test environment, a protocol that produces behavioral sensitization, or in the home cage, a protocol that fails to induce sensitization. In several brain areas amphetamine altered calmodulin content, but only in the group treated in a novel environment, suggesting that amphetamine-induced alterations in calmodulin may occur only when drug treatments induce behavioral sensitization.