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Related Experiment Videos

How far divergent evolution goes in proteins

A G Murzin1

  • 1Centre for Protein Engineering, MRC Centre, Cambridge, UK. agm@mrc-lmb.cam.ac.uk

Current Opinion in Structural Biology
|July 17, 1998
PubMed
Summary
This summary is machine-generated.

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Protein mutations can lead to new functions and structures. Recent protein structure determinations provide evidence of divergent evolution, revealing distant homologies between proteins with differing functions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Protein evolution can result in novel structures and functions.
  • Understanding divergent protein evolution is challenging due to the loss of ancestral information.
  • Recent advancements in protein structure determination offer new insights.

Purpose of the Study:

  • To investigate evidence of divergent evolution in proteins.
  • To explore the relationship between protein sequence, structure, and function.
  • To analyze new protein structure data for evolutionary insights.

Main Methods:

  • Determination of novel protein structures (ClpP proteases, steroid delta-isomerase, carboxypeptidase G2, triabin, chloroplast Rieske protein).
  • Comparative analysis of protein structures and sequences.

Related Experiment Videos

  • Bioinformatic analysis to identify distant homologies.

    • Main Results:

    • New structures provide insights into protein evolution.
    • Evidence of distant homology found between proteins with significant functional and structural differences.
    • Specific examples include ClpP proteases, steroid delta-isomerase, and others.

    Conclusions:

    • Divergent evolution leads to proteins with distinct functions and structures.
    • Structural data supports the concept of remote homology.
    • Recent structural studies enhance our understanding of protein evolutionary pathways.