Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Decrease of disaccharidase activity following application of bencyclan-hydrogenfumarate (author's transl)]

H Frisius, H Al-Abadi, H Heidrich

    Klinische Wochenschrift
    |September 15, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Der Internist·2017
    Same author

    Functional vascular diseases: Raynaud's syndrome, acrocyanosis and erythromelalgia.

    VASA. Zeitschrift fur Gefasskrankheiten·2010
    Same author

    Lithium niobate guided-wave network for a coherent receiver.

    Optics letters·2009
    Same author

    Automatic endless polarization control with integrated-optical Ti:LiNbO(3) polarization transformers.

    Optics letters·2009
    Same author

    Asymptomatic venous thrombosis in cancer patients--a problem often overlooked. Results of a retrospective and prospective study.

    VASA. Zeitschrift fur Gefasskrankheiten·2009
    Same author

    [15 years Amputierten-Initiative e.V].

    VASA. Zeitschrift fur Gefasskrankheiten·2009

    Bencyclan-hydrogenfumarate intraperitoneally administered to rats significantly decreased small bowel disaccharidase activity and altered villous height. Enzyme function recovered within 72 hours, suggesting no cytostatic effect but a notable drug influence.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Histology

    Context:

    • Investigating the effects of Bencyclan-hydrogenfumarate on gastrointestinal function.
    • Assessing the impact of drug administration on small bowel mucosal enzymes and morphology.

    Purpose:

    • To determine the effect of Bencyclan-hydrogenfumarate on rat small bowel disaccharidase activity.
    • To correlate functional changes with morphological alterations in the small intestine.

    Summary:

    • Intraperitoneal Bencyclan-hydrogenfumarate administration in rats dose-dependently reduced small bowel disaccharidase activity, with 100 mg/kg causing up to a 50% decrease.
    • Morphological changes, including reduced villous height and increased crypt depth, correlated with decreased enzyme activity.
    • Functional recovery within 72 hours suggests the drug's effect is not due to a persistent antimetabolic or cytostatic mechanism.

    Related Experiment Videos

    Impact:

    • Highlights the significant influence of Bencyclan-hydrogenfumarate on intestinal disaccharidase activity.
    • Suggests the need to consider these findings in clinical therapeutic applications of the drug.
    • Provides insights into the pharmacological effects of Bencyclan-hydrogenfumarate on the gastrointestinal system.