Related Experiment Video

Updated: Aug 15, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

[Ebstein's anomaly associated with left ventricular dysfunction: a case report]

T Maruo1, S Kano, K Ichino

  • 1Department of Cardiology, JR Tokyo General Hospital.

Journal of Cardiology
|July 17, 1998
PubMed

Insights

This case study highlights a 66-year-old man with Ebstein's anomaly, presenting with left ventricular dysfunction and heart failure symptoms. Diffuse fibrosis is suggested as a potential cause for his depressed systolic function.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Congenital Heart Disease

Background:

  • Ebstein's anomaly is a rare congenital heart condition affecting the tricuspid valve.
  • Patients may develop progressive heart failure and arrhythmias over time.
  • Left ventricular dysfunction in Ebstein's anomaly is less common but can significantly impact prognosis.

Observation:

  • A 66-year-old male with known Ebstein's anomaly presented with symptoms of heart failure, including lower extremity edema and orthopnea.
  • Physical examination revealed signs of right-sided heart strain and atrial fibrillation.
  • Echocardiography demonstrated significant tricuspid valve abnormalities, atrial and ventricular dilation, and paradoxical septal motion.

Findings:

  • Left ventriculography revealed diffuse hypokinesis with a reduced ejection fraction of 49%.
  • Transesophageal echocardiography showed a hypoplastic tricuspid valve with moderate regurgitation.
  • Coronary arteries were normal, ruling out ischemic heart disease.

Implications:

  • Diffuse myocardial fibrosis is proposed as a potential mechanism for the observed left ventricular systolic dysfunction in this patient.
  • This case underscores the importance of considering ventricular dysfunction in the long-term management of Ebstein's anomaly.
  • Further research into the pathophysiology of ventricular dysfunction in Ebstein's anomaly is warranted.

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...