Secretion of mucous granules and other membrane-bound structures: a look beyond exocytosis

The substances that animals secrete at epithelial surfaces include not only small molecules and ions delivered by exocytosis, but also a wide variety of materials in membrane-bound form. The latter include mucous granules of pulmonate molluscs, milk fat globules, and products of apocrine and holocrine secretion. Contents include hydrophobic entities (e.g., lipids, hydrocarbons), protective substances (e.g., mucus), and potentially injurious substances (e.g., digestive enzymes, toxins). In some cases vesicles or granules perform significant functions through enzymatic or other properties of the membrane itself (e.g., mammalian prostasome). Much work is still needed to elucidate the ways in which cells release membrane-bound products and how these products are deployed. The current concentration of research effort on exocytosis as a secretory modus should not divert attention from the remarkable versatility of epithelial cells that are capable of utilizing a variety of ways besides exocytosis to transfer materials and information to the external environment.