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Vitamin D and bone mineral density

D Collins1, C Jasani, I Fogelman

  • 1Department of Chemical Pathology, Guy's Hospital, London, UK.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|July 17, 1998
PubMed
Summary

Serum 25-hydroxyvitamin D (25OHD) levels significantly impact bone mineral density (BMD) in postmenopausal women. Higher 25OHD is associated with better BMD at both the lumbar spine and femur neck.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Geriatric Medicine

Background:

  • Postmenopausal osteoporosis is a significant health concern.
  • Bone mineral density (BMD) is a key indicator of bone health.
  • Factors influencing BMD require further investigation.

Purpose of the Study:

  • To investigate the relationship between serum 25-hydroxyvitamin D (25OHD) and bone mineral density (BMD) in postmenopausal women.
  • To identify other factors influencing BMD at the lumbar spine and femur neck.

Main Methods:

  • Cross-sectional study of 166 postmenopausal women (age 30-79).
  • Measurements included BMD (lumbar spine, femur neck), serum 25OHD, intact parathyroid hormone (PTH), and other biochemical markers.
  • Statistical analyses included correlation and stepwise multiple regression.

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Main Results:

  • BMD at the lumbar spine correlated positively with serum 25OHD and body mass index (BMI), and negatively with age.
  • BMD at the femur neck correlated positively with serum 25OHD and BMI, and negatively with age and PTH.
  • Age, BMI, and serum 25OHD were significant predictors of lumbar spine BMD.
  • Age, BMI, serum 25OHD, and PTH were significant predictors of femur neck BMD.

Conclusions:

  • Serum 25OHD levels contribute to bone mineral density at both the lumbar spine and femur neck in postmenopausal women.
  • Age, BMI, and PTH also play roles in determining BMD.
  • Maintaining adequate vitamin D levels may be crucial for bone health in this population.