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Related Experiment Videos

Ovarian function after autologous bone marrow transplantation

A D Schimmer1, M Quatermain, K Imrie

  • 1University of Toronto Autologous Blood and Marrow Transplant Program and the Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 17, 1998
PubMed
Summary

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Twenty-nine percent of women regain ovarian function after autologous bone marrow transplantation (ABMT). Younger age at transplantation is a key predictor of ovarian recovery, while total-body irradiation (TBI) may negatively impact function.

Area of Science:

  • Reproductive endocrinology
  • Hematology
  • Oncology

Background:

  • Autologous bone marrow transplantation (ABMT) is a critical treatment for various hematologic and oncologic conditions.
  • Ovarian function preservation is a significant concern for premenopausal women undergoing ABMT due to potential long-term effects of treatment.

Purpose of the Study:

  • To determine the frequency of return of ovarian function following ABMT.
  • To identify major factors predicting ovarian function recovery in women post-ABMT.

Main Methods:

  • Retrospective review of 200 women undergoing ABMT, with 17 meeting inclusion criteria (alive, disease-free, <50 years, premenopausal).
  • Ovarian function recovery defined by pregnancy, regular menses, absence of menopausal symptoms, and adequate estradiol levels off hormonal therapy.

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  • Statistical analysis, including log-rank test and univariate analysis, was used to identify predictive factors.

    • Main Results:

    • All 17 patients experienced immediate menopause post-ABMT.
    • Twenty-nine percent (5/17) of patients recovered ovarian function at a median of 24 months.
    • Younger age at transplantation (median 19 vs. 30 years) significantly predicted ovarian recovery (P = .03).
    • Total-body irradiation (TBI) showed a trend towards predicting sustained ovarian function loss (P = .067).

    Conclusions:

    • Despite initial menopause, a notable proportion of women can regain ovarian function after ABMT.
    • Younger patient age at the time of transplantation is a crucial factor for successful ovarian function recovery.
    • Total-body irradiation (TBI) may be associated with a higher risk of sustained ovarian function loss.