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Updated: Aug 7, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Synthesis utilizing insoluble polymers: new reactions and small molecules
1Oxford Diversity, 57 Milton Park, Abingdon, Oxon, OX14 4RX, UK. TBaxter@OA-OD.com
Abstract:
It can be argued that solid-phase organic chemistry is the preferred method of preparing screening libraries for lead compound discovery and lead optimization within the pharmaceutical industry. Solid-phase peptide chemistry is the most reliable and general of the synthetic methods available today; however, the purities of products are inadequate for the needs of the current market and the screening departments of pharmaceutical companies. Recent synthetic advances in solid-phase organic chemistry have started to increase the range of chemistry that can be used to prepare 'drug-like' small molecules in library format.
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