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Related Experiment Videos

New methods in combinatorial chemistry-robotics and parallel synthesis

J F Cargill1, M Lebl

  • 1Ontogen Corporation, 2325 Camino Vida Roble, Carlsbad, CA 92009, USA. John.Cargill@ontogen.com

Current Opinion in Chemical Biology
|June 1, 1997
PubMed
Summary

Automated parallel synthesis is advancing rapidly, mirroring the semiconductor industry

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Area of Science:

  • Chemical synthesis automation
  • Miniaturization in chemistry

Background:

  • Parallel synthesis enables rapid compound generation.
  • Current automation trends aim for efficiency and cost reduction.

Purpose of the Study:

  • To highlight technological advancements in automated parallel synthesis.
  • To discuss the impact of semiconductor industry models on chemical automation.

Main Methods:

  • Miniaturization of reaction formats.
  • Development of high-density reaction blocks.
  • Application of ink-jet dispensing for reagent delivery.
  • Synthesis within microfluidic devices.

Main Results:

  • Achieved miniaturization, increased speed, and reduced costs in parallel synthesis.
  • Demonstrated feasibility of high-density reaction blocks.
  • Successfully employed ink-jet dispensing and microchip synthesis.

Conclusions:

  • Automated parallel synthesis is adopting semiconductor industry principles.
  • These advancements promise more efficient and cost-effective chemical research.

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