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Protein NMR extends into new fields of structural biology
1Biomolecular Structure Unit, Glaxo Wellcome Research & Development, Gunnels Wood Road, Stevenage, SG1 2NY, UK. rc8817@ggr.co.uk
Current Opinion in Chemical Biology
|July 17, 1998
Abstract:
Advances in protein NMR have opened new doors for the understanding of macromolecular structure and interactions. Isotope-labelling approaches have extended the size limit for structure determination, the mapping of protein-ligand interactions is now widely used and has led to a new drug discovery approach, pathways of protein folding processes can be followed, and the structures of molecules from membranes can be determined.