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Treatment of polymicrobial intra-abdominal, pelvic, and diabetic foot infections
1Department of Medicine and Clinical Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Abstract:
Intra-abdominal, pelvic, and diabetic foot infections are generally polymicrobial. Antimicrobial resistance occurs commonly, complicating treatment. Among numerous therapeutic options, a beta-lactam with a beta-lactamase inhibitor, and newer fluoroquinolones, may be particularly useful in managing these infections.
Insights
Treating complex infections like intra-abdominal, pelvic, and diabetic foot requires effective strategies due to common antimicrobial resistance. Beta-lactam/beta-lactamase inhibitors and newer fluoroquinolones offer valuable options for managing these challenging polymicrobial infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Intra-abdominal, pelvic, and diabetic foot infections are frequently polymicrobial.
- Antimicrobial resistance is a common challenge in treating these infections, complicating therapeutic choices.
Purpose of the Study:
- To review and highlight effective antimicrobial agents for complex polymicrobial infections.
- To discuss the utility of specific antibiotic classes in managing challenging infections.
Main Methods:
- Literature review of current therapeutic options for polymicrobial infections.
- Analysis of antimicrobial resistance patterns and treatment efficacy.
Main Results:
- Beta-lactam/beta-lactamase inhibitor combinations show significant efficacy.
- Newer fluoroquinolones provide a valuable alternative for managing these infections.
Conclusions:
- Combination therapies and newer agents are crucial for overcoming antimicrobial resistance.
- Strategic selection of antimicrobials is key to successful treatment of polymicrobial infections.