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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2006
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Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women.

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Related Experiment Video

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Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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Secondary osteoporosis. Diagnostic considerations

K D Harper1, T J Weber

  • 1Bone and Metabolic Diseases Clinic, Duke University Medical Center, Durham, North Carolina, USA.

Endocrinology and Metabolism Clinics of North America
|July 21, 1998
PubMed
Summary

Secondary osteoporosis causes significantly impact bone loss and fracture risk. This article reviews key factors like hormonal imbalances, diseases, and medications contributing to osteoporosis.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Rheumatology

Background:

  • Osteoporosis is a significant public health concern, characterized by reduced bone density and increased fracture susceptibility.
  • While primary osteoporosis is common, secondary causes represent a substantial, often overlooked, contributor to bone loss.

Purpose of the Study:

  • To comprehensively review the diverse secondary causes of osteoporosis.
  • To highlight their contribution to bone loss and elevated fracture risk.

Main Methods:

  • Literature review of secondary osteoporosis etiologies.
  • Synthesis of information on hypogonadism, thyroxine excess, hyperparathyroidism, malignancies, gastrointestinal disorders, medications, lifestyle factors, and connective tissue diseases.

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Main Results:

  • Identified key secondary causes including hypogonadism, thyroid dysfunction, hyperparathyroidism, and various systemic diseases.
  • Highlighted the role of specific medications and lifestyle choices (vices) in accelerating bone loss.
  • Emphasized the link between connective tissue diseases and secondary osteoporosis.

Conclusions:

  • Recognizing and addressing secondary causes of osteoporosis is crucial for effective management.
  • Early diagnosis and intervention for these conditions can mitigate bone loss and reduce fracture incidence.