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A mouse bone marrow dosimetry model

M S Muthuswamy1, P L Roberson, D J Buchsbaum

  • 1Department of Radiation Oncology, University of Michigan, Ann Arbor, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|July 21, 1998
PubMed
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Accurate dosimetry for radioimmunotherapy in mice requires considering energy deposition from both within and surrounding bone marrow. This is crucial because mouse marrow dimensions are similar to beta particle ranges, impacting dose calculations for radionuclides like iodine-131.

Area of Science:

  • Medical Physics
  • Nuclear Medicine
  • Radiation Biology

Background:

  • Bone marrow is the primary dose-limiting organ in radioimmunotherapy (RIT).
  • Athymic nude mouse models are critical for guiding human RIT, but their bone marrow dimensions complicate dose calculations.
  • The comparable size of mouse marrow to beta particle ranges necessitates detailed energy deposition modeling.

Purpose of the Study:

  • To develop and validate a computational model for estimating bone marrow absorbed dose in mice during RIT.
  • To assess the impact of different bone marrow geometries and radionuclide properties on dose deposition.
  • To improve the accuracy of preclinical RIT dosimetry using mouse models.

Main Methods:

  • A computer simulation model was developed incorporating slab, spherical, and cylindrical bone marrow geometries.

Related Experiment Videos

  • Beta dose point kernels were used to estimate energy deposition for various beta-emitting radionuclides.
  • Calculations considered energy deposition from both within the marrow and from surrounding tissues.

    • Main Results:

    • Calculated energy deposition percentages in mouse marrow varied significantly by radionuclide (e.g., 46% for 131I, 10% for 90Y) using full geometry.
    • When considering marrow and whole-body sources, energy deposition percentages were 61% for 131I, 40% for 186Re, and 29% for 90Y.
    • These results highlight the significant contribution of external sources to marrow dose.

    Conclusions:

    • Accurate mouse bone marrow dose computation in RIT necessitates inclusion of energy loss from within the marrow.
    • Dose contributions from surrounding tissues are critical, especially for lower-energy beta emitters like 131I.
    • This modeling approach enhances the reliability of mouse models for human RIT dose assessment.