Related Experiment Videos
Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia
L Leventhal1, J P Mathis, G C Rossi
1Department of Psychology, Queens College, City University of New York, Flushing 11367, USA.
European Journal of Pharmacology
|July 21, 1998
Abstract:
Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/K-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.