Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular mechanisms that underlie structural and functional changes at the postsynaptic membrane during synaptic

H V Wheal1, Y Chen, J Mitchell

  • 1Neuroscience Research Group, School of Biological Sciences, University of Southampton, U.K.. wheal@soton.ac.uk

Progress in Neurobiology
|July 22, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoscopic treatment versus open excision for pediatric pilonidal disease: technical description of a modified (P)EPSiT approach using standard equipment and retrospective cohort study.

Techniques in coloproctology·2026
Same author

Therapy and long-term outcomes of acute anal fissure: a high-volume referral centre experience with 623 patients.

Techniques in coloproctology·2026
Same author

O<sub>3</sub> uptake and drought stress effects on carbon acquisition of ponderosa pine in natural stands.

The New phytologist·2021
Same author

Biofunctionalization of 3D-printed silicone implants with immunomodulatory hydrogels for controlling the innate immune response: An in vivo model of tracheal defect repair.

Biomaterials·2020
Same author

Effect of fluoride mouthrinses and stannous ions on the erosion protective properties of the in situ pellicle.

Scientific reports·2019
Same author

A predominant Th1 polarization is present in synovial fluid of end-stage osteoarthritic knee joints: analysis of peripheral blood, synovial fluid and synovial membrane.

Clinical and experimental immunology·2018

Neurodegeneration in the hippocampus triggers structural plasticity, leading to altered synaptic function and increased neuronal excitability. Molecular mechanisms involving neural recognition molecules and postsynaptic densities are crucial for these changes.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Synaptic plasticity is a key process in the brain, involving both structural and functional changes.
  • Neurodegeneration, modeled here by kainic acid-induced lesions in the hippocampus, significantly impacts synaptic function.
  • CA3 pyramidal cell degeneration leads to loss of afferent input to CA1 cells, initiating a cascade of plasticity events.

Purpose of the Study:

  • To review the structural and functional components of synaptic plasticity following neurodegeneration.
  • To explore the molecular machinery underlying these plastic changes.
  • To discuss the roles of specific molecules, including neural recognition molecules and postsynaptic density proteins, in synaptic plasticity.

Main Methods:

  • Review of existing literature on synaptic plasticity and neurodegeneration.

Related Experiment Videos

  • Analysis of studies using the kainic acid lesioned hippocampus model.
  • Examination of molecular mechanisms involving neural cell adhesion molecules, cadherins, amyloid precursor protein, LDL-R family, and postsynaptic density proteins.

    • Main Results:

    • Neurodegeneration induces structural plasticity, including synaptogenesis and changes in dendritic morphometry.
    • Increased NMDA to AMPA receptor ratio and altered LTP/LTD balance contribute to hyperexcitability and epileptiform activity.
    • Key molecular players identified include neural recognition molecules, LDL-R family, MAGUKs, and gephyrin, involved in synaptic structure, function, and receptor clustering.

    Conclusions:

    • Synaptic plasticity following neurodegeneration is a complex process involving intricate molecular machinery.
    • Understanding these molecular mechanisms is vital for insights into cognitive function, Alzheimer's disease, and neurological disorders.
    • Further research into postsynaptic membrane specializations will elucidate their role in neuronal communication and plasticity.