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Related Experiment Videos

A brainstem network mediating apneic reflexes in the rat

N L Chamberlin1, C B Saper

  • 1Department of Neurology, Harvard Medical School and Beth Israel Hospital, Boston, Massachusetts 02115, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 22, 1998
PubMed
Summary

Sensory-induced apnea, a protective reflex, is triggered by the intertrigeminal region in the pons. This area receives sensory input and connects to respiratory neurons, mediating airway reflexes.

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Area of Science:

  • Neuroscience
  • Respiratory Physiology
  • Sensory Reflexes

Background:

  • Apnea is a crucial protective reflex against airway irritation.
  • Central mechanisms of sensory-induced apnea remain unclear.
  • Previous research implicated the Kölliker-Fuse nucleus and trigeminoparabrachial pathway.

Purpose of the Study:

  • To identify the specific pontine sites responsible for sensory-induced apnea.
  • To characterize the neural pathways involved in these apneic reflexes.

Main Methods:

  • Chemical microstimulation in the pons.
  • Anterograde and retrograde axonal tracing.
  • Histological analysis of neural pathways.

Main Results:

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  • Apneic responses were consistently elicited from the intertrigeminal region, ventral to the Kölliker-Fuse nucleus.
  • This region projects to the ventral respiratory group in the ventrolateral medulla.
  • The intertrigeminal region receives sensory input from the spinal trigeminal nucleus and nucleus of the solitary tract.

Conclusions:

  • The intertrigeminal region is a key site for sensory-induced apnea.
  • It integrates sensory information from the airway.
  • This region acts as a common pathway linking sensory input to respiratory neurons mediating apnea.