Related Experiment Video
Updated: Aug 19, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
Interhemispheric disconnection syndrome in Alzheimer's disease
Y Lakmache1, M Lassonde, S Gauthier
1Groupe de Recherche en Neuropsychologie Expérimentale, Département de Psychologie, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, PQ, Canada H3C 3J7.
Abstract:
It is commonly acknowledged that patients with Alzheimer's disease show memory and cognitive deficits that result from their cerebral histopathological abnormalities. We report new evidence showing that they also manifest deficits in interhemispheric integration of information, probably reflecting a corpus callosum dysfunction. Patients were given a battery of motor, somatosensory, and visual tests that had to be carried out by using either one or both hemispheres. Tasks were chosen such that subjects with Alzheimer's disease performed normally when using intrahemispheric processing. They, however, performed poorly when interhemispheric communication was required. This observation attests to the presence of a disconnection syndrome and suggests that these interhemispheric tasks can serve as diagnostic tools for the early assessment of their dementia.
More Related Videos
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
07:03Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Cerebral Hemispheres
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction
Hepatic Encephalopathy