Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modelling the major histocompatibility complex susceptibility to RA using the MASC method

E Génin1, M C Babron, M F McDermott

  • 1INSERM U155, Paris, France. genin@allele5.biol.berkeley.edu

Genetic Epidemiology
|July 22, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Barium ion sensing with IPG K<sup>+</sup> molecular probes.

The Analyst·2025
Same author

Understanding physician preferences about combined thrombolysis and thrombectomy in patients with large vessel occlusion: An international cross-sectional survey.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2024
Same author

An unmet need: Pancreatic beta cell replacement.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Demonstration of event position reconstruction based on diffusion in the NEXT-white detector.

The European physical journal. C, Particles and fields·2024
Same author

First Constraints on Heavy QCD Axions with a Liquid Argon Time Projection Chamber Using the ArgoNeuT Experiment.

Physical review letters·2023
Same author

Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

Physical review letters·2022

Investigating rheumatoid arthritis (RA) genetic susceptibility, this study analyzed HLA-DRB1 and TNF-LT loci. Findings suggest TNF data significantly refines understanding beyond HLA-DRB1 alone, rejecting prior hypotheses.

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Human Genetics

Background:

  • Rheumatoid arthritis (RA) genetic susceptibility is linked to HLA-DRB1.
  • Two hypotheses exist: direct DRB1 role or a linked recessive gene.

Purpose of the Study:

  • To investigate the association between HLA-DRB1 and TNF-LT loci in RA.
  • To test the shared epitope and linked recessive gene hypotheses.

Main Methods:

  • Analysis of HLA-DRB1 and TNF-LT loci in 49 affected sib-pairs.
  • Utilized the Marker Association Segregation Chi-square (MASC) method.
  • Jointly analyzed genotype distribution and haplotype sharing.

Main Results:

  • HLA-DRB1 data alone supported both hypotheses.

Related Experiment Videos

  • Inclusion of TNF-LT data strongly rejected both hypotheses.
  • TNF data provided crucial additional information for RA genetic susceptibility.

    • Conclusions:

    • The combined analysis of HLA-DRB1 and TNF-LT offers a more comprehensive understanding of RA genetics.
    • TNF-LT data is essential for accurately modeling RA susceptibility in this region.
    • Revises understanding of genetic factors contributing to rheumatoid arthritis.