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Related Experiment Videos

Exercise and cardiovascular disease: a new perspective

R Shern-Brewer1, N Santanam, C Wetzstein

  • 1Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|July 22, 1998
PubMed
Summary

Exercise impacts LDL oxidizability differently based on duration and sex. Short-term exercise increases LDL oxidation risk, while chronic exercise in men reduces it, with no adverse effect seen in women.

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Area of Science:

  • Cardiovascular Science
  • Exercise Physiology
  • Lipid Metabolism

Background:

  • Low-density lipoprotein (LDL) oxidation is implicated in atherogenesis.
  • Exercise, despite inducing oxidative stress, is protective against cardiovascular disease.

Purpose of the Study:

  • To investigate the effect of exercise on LDL oxidizability.
  • To determine if exercise duration and sex influence LDL oxidation susceptibility.

Main Methods:

  • Study 1: Compared LDL oxidizability (copper-induced in vitro oxidation lag time) in short-term exercisers versus sedentary controls.
  • Study 2: Used group x sex ANOVA to analyze LDL oxidizability in male and female exercisers and sedentary subjects, adjusting for various factors.
  • Measured vitamin E and alpha-tocopherol levels.

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Main Results:

  • Study 1 showed enhanced LDL oxidizability in exercisers, attributed to preformed lipid peroxides, not decreased vitamin E.
  • Study 2 revealed chronic exercise (>2 years) significantly decreased LDL oxidation susceptibility in men, but not women.
  • Short-term exercise (<1 year) increased LDL oxidizability, suggesting a more oxidative environment.

Conclusions:

  • Chronic aerobic exercise (> several months) reduces LDL oxidation susceptibility in men.
  • Short-term aerobic exercise may increase LDL oxidation risk due to a more oxidative environment.
  • Aerobic exercise does not appear to negatively impact LDL oxidizability in women.