Sinoaortic denervation produces sodium retention in Dahl salt-sensitive rats

The role of the arterial baroafferent signals in sodium (Na) homeostasis was examined in salt-sensitive rats. Sodium balances, water balances, and systolic arterial pressure (SAP) were measured for 3 weeks in sinoaortic denervated (SAD) or sham denervated (Sham) Dahl salt-sensitive (S) and salt-resistant (R) rats fed a standard-salt diet (0.4% NaCl). In R rats, there was no significant difference in Na balance, water balance, or SAP between the SAD and Sham animals. In the S rats, urinary Na excretion was suppressed in the SAD but not in the Sham animals, resulting in Na retention. SAD significantly increased SAP and mean arterial pressure. High salt challenge (8% NaCl diet) markedly increased SAP and Na and water balances in both S-SAD and S-Sham rats. However, no significant difference was found in SAP or cumulative Na and water balances between S-SAD and S-Sham rats. These results suggest that the baroafferent signals may have some role on the regulation of Na balance in salt-sensitive animals under a standard-salt condition, although a high-salt load masked the baroafferent-dependent sodium excretion.