Absorption and metabolism of short-chain fatty acids in ruminants

Short-chain fatty acids (SCFA), viz. acetate, propionate and butyrate are quantitatively important substrates in ruminant energy metabolism. In the reviewed literature, 16 44% of ME intake was recovered as portal appearance of SCFA. This is considerably lower than expected when related to the estimated intragastric flux of SCFA. The discrepancy is caused by portal drained viscera metabolism of arterially abundant metabolites e.g., acetate and the metabolism of acetate and butyrate to acetoacetate and D-3-hydroxybutyrate in the absorptive epithelia. Even though considerable variations between experiments on acetate and propionate appearance are found, there seems to be a great deal of evidence that the proportion of gastrointestinally produced acetate and propionate absorbed to the portal blood is 50-75%. The portal recovery of butyrate has been found to be between 10 and 36% dependent on intraruminal infusion rate. It is concluded that major parts of acetate and propionate are directly absorbed to the portal vein. The true absorption rate of acetate can only be estimated by taking the portal drained viscera metabolism of arterial acetate into account. Butyrate is generally found to have a low recovery in the portal vein, but the production of D-3-hydroxybutyrate seems to be underestimated in major parts of the literature. It is therefore necessary to measure portal appearance as well as portal drained viscera metabolism to assess the quantitative as well as the qualitative contribution of SCFA and SCFA metabolites to whole animal metabolism.