Nodular amyloidosis of the tongue

Amyloidosis is a rare disease in otorhinolaryngology. It presents a wide range of clinical manifestations and its deposits can be found in various organs. In the paper, a case of a 73-year-old female patient with macroglossia, as a symptom of nodular amyloidosis is reported. The predominant features were dysphagia and speech impairment caused by the tongue protruding beyond the teeth. The histologic appearance consisted of a nodular pattern of amyloid deposition. The amyloid was of an AL (lambda-light chain) type as shown immunohistochemically. The presented case shows the importance of investigating the patient for co-existing disease.