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Gene regulation by vitamin D3

C Carlberg¹, P Polly

¹Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, Germany.

Critical Reviews in Eukaryotic Gene Expression

|July 23, 1998

Summary

This review discusses how vitamin D (VD) and its receptor (VDR) regulate gene transcription. It highlights common and unique features of VDR-mediated transcriptional regulation, crucial for cellular processes.

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Area of Science:

Endocrinology
Molecular Biology
Genetics

Background:

Vitamin D (VD), 1 alpha,25-dihydroxyvitamin D3, is a nuclear hormone regulating calcium homeostasis, bone formation, cell differentiation, apoptosis, and proliferation.
The actions of VD are mediated by the vitamin D receptor (VDR), a transcription factor belonging to the nuclear receptor superfamily.

Purpose of the Study:

To critically discuss the common and individual characteristics of VDR-mediated transcriptional regulation.
To explore the VDR's role as a transcription factor within the nuclear receptor superfamily.

Main Methods:

Literature review of VDR-mediated transcriptional regulation.
Comparative analysis of VDR with other nuclear receptors.

Main Results:

VDR shares structural and functional similarities with other nuclear receptors in DNA binding and transactivation.
VDR exhibits unique properties distinct from its relatives, influencing specific cellular signaling pathways.

Conclusions:

VDR-mediated transcriptional regulation involves both conserved mechanisms and unique characteristics.
Understanding these aspects is crucial for elucidating VD's pleiotropic effects and VDR's role in cellular signaling.

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