Diagnosis and management of weight loss in the elderly

Weight loss occurs commonly in elderly individuals, and is associated with functional decline and mortality. A 10% loss of body weight over 10 years is consistently associated with increased mortality and functional decline. A 4% body weight loss over 1 year should trigger a search for causes, which commonly include depression, cancers, benign gastrointestinal conditions, and medication toxicity. To evaluate weight loss, physicians should distinguish between four problems: anorexia, dysphagia, weight loss despite normal intake, or socioeconomic problems. In most cases, the cause of weight loss is identified by a thorough history, a targeted physical examination, and a simple laboratory evaluation. Assessment should include evaluation of functional and nutritional status. Management should include correction of potential causes and nutritional supplementation.