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Related Experiment Videos

Neural crest development: the interplay between morphogenesis and cell differentiation

C A Erickson1, M V Reedy

  • 1Section of Molecular and Cellular Biology, University of California-Davis 95616, USA.

Current Topics in Developmental Biology
|July 23, 1998
PubMed
Summary
This summary is machine-generated.

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Avian neural crest cells undergo epithelial-mesenchymal transformation for separation and migrate via environment-directed or phenotype-directed pathways, influencing their differentiation and positioning during embryogenesis.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Embryogenesis

Background:

  • Tissue pattern formation in embryogenesis involves differentiation and morphogenesis.
  • Avian neural crest cells exemplify the study of these developmental processes.
  • Neural crest cell migration initiates with epithelial-mesenchymal transformation.

Purpose of the Study:

  • To elucidate the mechanisms of neural crest cell separation from the neural epithelium.
  • To investigate the distinct migratory pathways and their regulatory models in avian embryos.
  • To propose a re-evaluation of patterning mechanisms for neural crest derivatives.

Main Methods:

  • Modeling of neural crest cell separation mechanisms (asymmetric mitosis, tractional force, loss of adhesion molecules).

Related Experiment Videos

  • Analysis of neural crest cell migration pathways (ventral and dorsolateral) in chick embryos.
  • Data interpretation to support environment-directed and phenotype-directed models of migration.

    • Main Results:

    • Epithelial-mesenchymal transformation drives neural crest lineage segregation.
    • Ventral pathway migration is primarily controlled by environmental cues (environment-directed model).
    • Dorsolateral pathway migration is dependent on melanoblast specification (phenotype-directed model).

    Conclusions:

    • The phenotype-directed model for neural crest cell migration may be more prevalent than previously thought.
    • Environmental cues and intrinsic cell phenotype play critical roles in neural crest development.
    • These findings necessitate a re-examination of patterning for various neural crest derivatives.