Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anthelmintics and ion-channels: after a puncture, use a patch

R J Martin1, I Murray, A P Robertson

  • 1Department of Preclinical Veterinary Sciences, University of Edinburgh, U.K. R.J.Martin@ed.ac.uk

International Journal for Parasitology
|July 23, 1998
PubMed
Summary

Avermectins and nicotinic agonists target nematode ion-channels. Understanding these anthelmintic targets and their resistance mechanisms can inform the development of more effective drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extended p_{3/2} Neutron Orbital and the N=32 Shell Closure in ^{52}Ca.

Physical review letters·2023
Same author

Dosimetry of Bone Seeking Beta Emitters for Bone Pain Palliation Metastases.

Seminars in nuclear medicine·2021
Same author

Pairing Forces Govern Population of Doubly Magic ^{54}Ca from Direct Reactions.

Physical review letters·2021
Same author

Systemic Radiotherapy of Bone Metastases With Radionuclides.

Clinical oncology (Royal College of Radiologists (Great Britain))·2020
Same author

Recording drug responses from adult Dirofilaria immitis pharyngeal and somatic muscle cells.

International journal for parasitology. Drugs and drug resistance·2020
Same author

Two-Neutron Halo is Unveiled in ^{29}F.

Physical review letters·2020

Area of Science:

  • Molecular pharmacology
  • Neurobiology
  • Parasitology

Background:

  • Major anthelmintics, avermectins and nicotinic agonists, target nematode ligand-gated ion channels.
  • Avermectins activate glutamate-gated chloride channels, while nicotinic agonists target nicotinic acetylcholine receptors.

Purpose of the Study:

  • To explore advances in understanding the molecular structure of nematode ion-channel receptors.
  • To investigate anthelmintic mechanisms of action and resistance using electrophysiological techniques.

Main Methods:

  • Two-micro-electrode voltage clamp to measure membrane resistance.
  • Patch-clamp technique to record single ion-channel currents.
  • Electrophysiological analysis of nematode ion-channel receptors.

Related Experiment Videos

Main Results:

  • Evidence suggests heterogeneity in nematode nicotinic acetylcholine receptors.
  • Avermectins may interact with multiple sites on their target receptors.
  • Receptor heterogeneity could influence the development of anthelmintic resistance.

Conclusions:

  • The molecular structure of nematode ion-channel receptors is complex and potentially heterogeneous.
  • Anthelmintics with multiple sites of action may reduce the probability of resistance development.
  • The MISER concept supports the use of multi-target anthelmintics to combat resistance.