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[Duodenogastric reflux: validation study of its endoscopic visualization]
P Ortiz1, G Santibáñez, E Briones
1Sección de Gastroenterología, Hospital Guillermo Grant B, Facultad de Medicina, Universidad de Concepción, Chile.
Revista Medica De Chile
|July 23, 1998
Summary
Endoscopic visualization of duodenogastric reflux correlates with total bile acid quantification in gastric content. This study links visual reflux signs during endoscopy to measurable bile acid levels, aiding diagnosis.
Area of Science:
- Gastroenterology
- Diagnostic Methods
- Reflux Studies
Background:
- Duodenogastric reflux, while normal, can harm the esophagus and stomach.
- Current methods for measuring reflux are not definitive.
Purpose of the Study:
- To compare endoscopic findings of duodenogastric reflux with bile acid levels.
- To establish a quantitative measure for reflux assessment.
Main Methods:
- Assessed duodenogastric reflux via endoscopic bile staining in 62 patients.
- Quantified total bile acids (QTBA) in fasting gastric content using an enzymatic method post-endoscopy.
Main Results:
- Median QTBA was 0.205 mumol/gastric residue.
- Patients with higher QTBA (> median) showed significantly more visible reflux during endoscopy (14/31) compared to those with lower QTBA (1/31).
- A strong statistical association (p < 0.001) was found between visible reflux and QTBA.
Conclusions:
- Endoscopic visualization of duodenogastric reflux is statistically linked to QTBA.
- QTBA measurement offers a quantitative correlate to endoscopic assessment of reflux.