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Systemic calciphylaxis associated with massive gastrointestinal hemorrhage

D F Brown1, C F Denney, D K Burns

  • 1Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235, USA.

Archives of Pathology & Laboratory Medicine
|July 23, 1998
PubMed
Summary

Calciphylaxis, a rare condition, can cause severe skin necrosis and extensive gastrointestinal bleeding. This case highlights calciphylaxis leading to massive GI hemorrhage, emphasizing its link to visceral injury.

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Area of Science:

  • Nephrology
  • Dermatology
  • Gastroenterology

Background:

  • Calciphylaxis is a severe condition often seen in patients with end-stage renal disease (ESRD).
  • It is characterized by vascular calcification and skin necrosis.

Observation:

  • A 38-year-old woman with diabetes, hypertension, and ESRD presented with digital ischemia and lower extremity necrosis.
  • She also developed extensive gastrointestinal ulceration and hemorrhage.

Findings:

  • Mesenteric arteriogram showed stenotic areas and filling defects, suggesting vasculitis.
  • Antemortem skin biopsy and postmortem examination confirmed calciphylaxis.
  • This case is the first documented instance of calciphylaxis associated with massive gastrointestinal hemorrhage.

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Implications:

  • This case reinforces the association between calciphylaxis and visceral organ injury.
  • It underscores the potential for severe gastrointestinal complications in calciphylaxis.
  • Further research into the mechanisms and management of calciphylaxis-related GI bleeding is warranted.