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Existence of striatal nerve cells coexpressing CCK(B) and D2 receptor mRNAs
A C Hansson1, A Andersson, B Tinner
1Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Neuroreport
|July 23, 1998
Abstract:
Co-localization of CCK(B) and D2 receptor mRNAs was analysed in adjacent sections of nucleus caudate putamen of the rat by means of in situ hybridization. A distinct subpopulation of D2 mRNA containing striatal nerve cells (in the order of 10%) was shown to co-express CCK(B) and D2 receptor mRNAs. All the CCK(B) receptor mRNA-positive nerve cells were co-localized with D2 receptor mRNA. These results give one morphological substrate to the previously demonstrated CCK(B)/D2 receptor interactions in the striatum.