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Lactation suppresses diurnal rhythm of serum leptin
L Pickavance1, M Tadayyon, G Williams
1Department of Medicine, University of Liverpool, United Kingdom.
Biochemical and Biophysical Research Communications
|July 24, 1998
Abstract:
Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in lactating rats. Thus the link between nocturnal food intake and increased serum leptin is broken during lactation and the hypoleptinaemia may be an important factor promoting the hyperphagia of lactation.