Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutation spectra of complex mixtures

D M DeMarini1

  • 1Environmental Carcinogenesis Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. demarini.david@epamail.epa.gov

Mutation Research
|July 24, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zebrafish irritant responses to wildland fire-related biomass smoke are influenced by fuel type, combustion phase, and byproduct chemistry.

Journal of toxicology and environmental health. Part A·2021
Same author

Mutagenicity and chemical analysis of emissions from the open burning of scrap rubber tires.

Environmental science & technology·2011
Same author

Predictive models for carcinogenicity and mutagenicity: frameworks, state-of-the-art, and perspectives.

Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews·2009
Same author

Comparison of biomarkers in workers exposed to 2,4,6-trinitrotoluene.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2007
Same author

Outdoor air pollution and DNA damage.

Occupational and environmental medicine·2006
Same author

World at work: charcoal producing industries in northeastern Brazil.

Occupational and environmental medicine·2005
Same journal

Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

Mutation research·2026
Same journal

Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

Mutation research·2026
Same journal

IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

Mutation research·2026
Same journal

Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

Mutation research·2026
Same journal

The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

Mutation research·2026
Same journal

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research·2026
See all related articles

Mutation spectra of complex mixtures, like cigarette smoke, can be predicted by dominant chemical classes. This finding aids molecular epidemiology by linking environmental mutagen effects in Salmonella to human tumor mutations.

Area of Science:

  • Toxicology and Mutagenesis
  • Environmental Health
  • Molecular Epidemiology

Background:

  • Determining mutation spectra of complex mixtures has been limited, primarily to studies in Salmonella.
  • Environmental exposures involve complex mixtures, necessitating methods to understand their mutagenic impact.
  • Previous research focused on simple mixtures or single compounds, leaving a gap in understanding complex environmental mutagens.

Purpose of the Study:

  • To review and summarize studies on mutation spectra of complex mixtures and their components.
  • To investigate the relationship between mutation spectra induced by environmental mutagens in Salmonella and human cancers.
  • To assess the utility of modeling complex mixture mutation spectra using predominant chemical classes or single compounds.

Main Methods:

Related Experiment Videos

  • Review of existing studies involving complex mixtures (e.g., urban air, cigarette smoke, chlorinated water) and their chemical fractions.
  • Analysis of mutation spectra induced by these mixtures and representative single compounds in Salmonella.
  • Comparison of Salmonella mutation spectra with mutation patterns observed in human tumors (e.g., p53 gene) linked to environmental exposures.

Main Results:

  • Mutation spectra of complex mixtures often reflect the dominance of one or a few chemical classes.
  • Mutation spectra of sunlight and cigarette smoke in Salmonella showed similarities to mutations in human skin and lung tumors.
  • A primary class of mutation is frequently observed across different mutagens within or even between chemical classes.

Conclusions:

  • Complex mixture-induced mutation spectra can be modeled by their predominant mutagenic chemical class or a single model compound.
  • These findings establish mechanistic links between environmental mutagens, experimental models (Salmonella), and human disease.
  • The results are valuable for interpreting mutation spectra in molecular epidemiology studies involving complex mixture exposures.